12 May 2003 - Madeleine Beth McCann is born to Kate and Gerry McCann at Glenfield Hospital in Leicester.
3 May 2007 - Kate and Gerry McCann tuck their daughter Madeleine and her two-year-old twin brother and sister Sean and Amelie into bed and head for dinner with some friends at a nearby tapas restaurant, which is about 100 yards away from the sleeping children.
3 May 2007 - Three-year-old Madeleine McCann disappears from her family's apartment in Praia da Luz (The Beach of Light"). The initial investigation by the Guarda Nacional Republicana reaches the conclusion that Madeleine McCann had been abducted.
5 May 2007 - As the search for Madeleine continues, her parents issue a statement that says they "cannot describe the anguish and despair" they are feeling, and added that "if you have Madeleine, let her come home to her mummy, daddy, brother and sister."
8 May 2007 - Portuguese daily newspaper Correio de Manha reports that Madeleine may have been kidnapped by a pedophile ring.
11 May 2007 - Portuguese police call off ground searches for Madeleine McCann after no traces of the toddler were found.
12 May 2007 - Gerry and Kate McCann restate international calls for help on what would have been Madeleine's fourth birthday.
13 May 2007 - Up to half a million pilgrims attending the 90th anniversary of the first appearance of the Virgin Mary at the Sanctuary of Fatima pray for Madeleine's safe return.
15 May 2007 - British citizen Robert Murat is made an official arguido ("suspect") after a search of his mother's villa. Murat came to the attention of police by the British press after he repeatedly crossed the police tape outside the crime scene. Casa Liliana is located a mere 150 yards from the apartment where Madeleine went missing.
17 May 2007 - Official web site, FindMadeleine.com, is launched.
26 May 2007 - Based upon a witness report, the description of a man seen on the night Madeleine disappeared "carrying a child or an object that could have been taken as a child" is broadcast by Portuguese police.
30 May 2007 - Gerry and Kate McCann meet the Pope at a general audience in Rome at the start of a European tour to raise public awareness of Madeleine's disappearance.
6 June 2007 - Sabina Mueller of German Radio asks the McCanns how they feel about the fact that "more and more people seem to be pointing the finger" at them. This is perhaps the first indication that media attention is shifting toward the McCanns as perpetrators of the crime.
12 June 2007 - The McCanns return to Portugal after their tour of Europe. Gerry McCann tells reporters that he and Kate "certainly want to take time to reflect on what has been achieved and how best we can help the investigation."
17 June 2007 - Chief Inspector Olegario Sousa admits that vital forensic clues might have been destroyed in the hours after Madeleine's disappearance, as the scene was not properly secured. He noted that "the presence of so many people - especially in the room where the little girl slept with her brother and sister - could have at least complicated the work of the forensic team."
10 July 2007 - Suspect Robert Murat questioned again by Portuguese police. "We will be conducting more interviews,” said Chief Inspector Olegario Sousa to reporters afterward.
29 July 2007- British sniffer dogs are flown to Portugal. Keela and Eddie work in the apartment and several cars, including the car the McCanns rented some 25 days after Madeleine disappeared.
6 August 2007 - Police fail to find any new evidence after a search of the home of Robert Murat following a two-day, multi-jurisdictional effort.
7 August 2007 - Forensic tests begin in a British lab on traces of blood found by sniffer dogs in Madeleine's apartment.
11 August 2007 - Police in Portugal publicly state for the first time that, in light of emerging evidence, Madeleine may be dead. Chief Inspector Sousa adds that Gerry and Kate McCann are not being considered as suspects following newspaper speculation that they were under police suspicion.
17 August 2007 - Portuguese police announce that they are "not seeking any suspects" at the time, and that there are three undisclosed hypothetical scenarios they are pursuing.
24 August 2007 - Portuguese police acknowledge that they still have doubts over how Madeleine disappeared and whether the child will ever be found.
31 August 2007 - Gerry and Kate McCann initiate a libel suit against the Portuguese newspaper Tal & Qual. The paper printed that "police believe" the McCanns killed their daughter.
6 September 2007 - Portuguese police interview Kate McCann for 11 hours as a witness in the presence of her lawyer. In addition, Portuguese detectives confirm they have the partial results of forensic tests by a UK laboratory.
7 September 2007 - Madeleine's mother is declared an official suspect and fears she could be charged in the disappearance of Madeleine, family friends say. Gerry McCann is also named as a formal suspect following additional questioning.
9 September 2007 - The McCann family returns to England with the full knowledge and agreement of Portuguese police.
10 September 2007 - Portuguese police announced that they will be sending an investigative report to prosecutors detailing their recent findings, and that prosecutors would determine whether or not to charge Kate and Gerry McCann with any crimes in the disappearance of Madeleine.
13 September 2007 - The Daily Mail quotes unnamed Portuguese police sources who suuggest that Madeleine McCann died as a result of an overdose of sleeping medication. DNA samples obtained from the rental car the McCanns used 25 days after the disappearance of Madeleine reportedly showed traces of an undisclosed sleep aid.
15 September 2007 Gerry and Kate McCann announce a $160,500 ad campaign aimed at keeping the search for Madeleine McCann a top priority in Spain, Portugal, and "other parts of Europe."
20 September 2007 - Gerry and Kate McCann hired Rogerio Alves, one of Portugal's top lawyers, to lead their defense team.
25 September 2007 - A possible photo of Madeleine McCann surfaced, taken by tourists in Morocco in late August 2007.